Tag Archives: Freedom

Curcumin vs Autoimmune Diseases

Over recent decades, researchers conducted 32 clinical trials on the effect of curcumin supplements on various autoimmune diseases including osteo/rheumatoid arthritis, type 2 diabetes and ulcerative colitis. Those trials formed part of the basis for us here at Fully Human including curcumin in Freedom, so let’s see what the current state of the science is.

All studies were randomized, placebo controlled trials, the gold standard for medical evidence. The trial lengths ranged from 4-40 weeks. And they looked at a variety of clinical measures including pain, stiffness, range of motion, and disease specific markers (inflammatory markers for RA as an example).

Overall, 26 trials resulted in significant improvements with most of the remainder not being long enough to report results. None reported significant side effects, and none reported curcumin supplementation as being anything but supportive as an autoimmune therapy.

Osteoarthritis Results

The osteoarthritis-related trials ranged from 6 to 40 weeks with doses ranging from 100–2000 mg/day tested. In 13 of the studies, dietary curcumin intake resulted in improvement of at least 2 clinical measures (pain, stiffness, range of motion…etc) and seven studies showed improvement of at least three clinical measures. The average effective daily dose was 829mg/day divided between at least two doses.

Type 2 Diabetes Results

The Type 2 diabetes trials ranged from 4 to 36 weeks with doses of curcumin ranging from 200 to 1500 mg/day. All eight studies showed curcumin supplementation possessed anti-diabetic effects with the average effective daily dosage being 570.79 mg/day divided between at least two doses.

Ulcerative Colitis Results

The duration of the three studies looking at ulcerative colitis ranged from 4 weeks to 24 weeks with doses ranging from 140 mg to 3000 mg/day. Two of the three studies showed taking between 2,000-3,000mg/day were effective in putting mild-moderate ulcerative colitis into remission.

Other Results

There have been only three studies of curcumin’s effect on other rheumatic diseases, including two studies on rheumatoid arthritis and one on lupus nephritis. Of the two RA studies, one 8-week study showed an improvement in patients taking 1,000mg/day divided between at least two doses. The other study was only two weeks long, and didn’t end with any reportable outcome. The lupus study found that a dose as low as 66mg/day over 12 weeks resulted in significant improvements in systolic blood pressure and a levels of lupus markers in the blood (proteinuria and hematuria).

Promising results aside, due to the limited number of studies conducted on RA and LN, the effect of curcumin on RA and lupus should be considered possibly useful, but with clinically inconclusive evidence.

Freedom Is The Answer

Do you suffer from one of these conditions? Try our patent-pending blend of turmeric curcumin (even more potently extracted than the ones referenced in these studies).

References
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  37. Lang A., et al. Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin. Gastroenterol. Hepatol. 2015;13:1444–1449. doi: 10.1016/j.cgh.2015.02.019. [PubMed]
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Can Boswellia Manage Knee Arthritis?

In 2018 a group of researchers from New Jersey conducted a four month clinical trial to evaluate the safety and efficacy of a Boswellia serrata extract (BSE). This study was longer than any other previous clinical trial on patients with osteoarthritis (OA) of the knee. It’s key finding is that an increasing the potency of the Boswellia extract increases its biologically active components. These then act together against inflammation and arthritis. The end result, published in early 2019, was an improvement in physical and functional ability while also reducing the pain and stiffness.

The study randomized 48 patients, aged 35-75, with OA of the knee into active and placebo groups. All participants, were selected because they had a history of OA, and pain in their knees that was difficult to bear on most days.

Background on Boswellia

Boswellic acids, especially one called AKBA, are powerful anti-inflammatories. They block an enzyme called 5-lipoxygenase (5-LOX) that breaks down polyunsaturated fatty acids in foods into leukotrienes, inflammatory molecules that attack joints and other tissues. Boswellia may also help reduce cartilage damage in arthritis. It also shows promise as a cancer treatment.

Various research studies show derivatives of boswellic acids (BAs) are not all created equal, but all help reduce inflammation to one degree or another. Earlier clinical studies found boswellic acid‐containing products in combination with Curcumin C3 Complex® and ginger extract were better at reducing arthritis pain than individual supplements alone.

Results

The bottom line is that Boswellia serrata, given three times a day, significantly reduced pain and stiffness and improved the joints of those taking it. Best of all, this study found there there were no adverse effects.

How much did it reduce them?

Pain: Patients reported a 45-50% reduction in their pain levels, as judged on a 1-10 scale. While the placebo group reported only a 5-10% reduction.

Stiffness: The stiffness metric was measured by how far the participants could walk without pain in 6 minutes. For the patients taking Boswellia, they increased their distance by over a third, while the other group reported no change.

But the most significant change is seen in the image below. The patients taking Boswellia actually saw a reduction in bone spurs, and an increase in joint space.

Freedom Is The Answer

Do you suffer from OA in your knees? Do you have a hard time walking without pain? Try our patent-pending blend of Boswellia (even more potently extracted than the one studied here). It isn’t cheap, but then again, removing bone spurs isn’t cheap either.

Quality Testing

Freedom is made in a contract CGMP manufacturing facility certified under 21 CRF Part III. This facility is registered with the FDA and certified by the State of Washington for dietary supplement manufacturing.

All processing and manufacturing is done in isolated production rooms (clean-rooms) to prevent any cross contamination of ingredients and products. Before and after each production run the production rooms are cleaned and sanitized to prevent cross-contamination, however the manufacturing facility does process gluten at times. Contact us if you need to know more about this.

We designed our testing protocol using a NSF hazard analysis program. Since every raw material has a unique microbial or environmental adulteration hazard (such as radiation), each material has a predetermined testing protocol suited to its own risk level. Regardless of how low the risk level is determined to be, every raw material is tested using USP and or AHPA recommended standards.

  • We require 100% testing using USP method 1119 (Near-Infrared spectroscopy, a scientific process that uses chemometric models to identify all raw materials). Our reference standards are third-party laboratory-verified, certifying their validity. Our hand selected third-party laboratory holds the international ISO 17025 certificate.
  • We conduct regular audits of our outside laboratory partners and qualify their results eliminating “dry labbing” dangers.
  • Environmental testing for microbiological bio-burden hazards is an integral part of the testing program designed by our manufacturer. Introduction of microbial adulterants during holding or processing is monitored utilizing USP Method 1116 for continued evaluation of microbial limits in controlled areas.  This method was adopted voluntarily, from the FDA’s pharmaceutical codes. Dietary supplement regulations do not require this, but we believe it is imperative for quality.

These testing models are then used to assure that products meet all intended identity, strength, and composition specifications unique to each finished product batch. Finally, every finished batch is tested again for microbial adulteration, thus assuring that every batch meets our purity standards.

Cost of Freedom

Yea, I just did that. It is corny, sorry. But the single most frequent question I have had over the past week has been “why does your supplement cost so much?” Not an unreasonable question for a product that is nearly $100 for a month’s supply. So without further ado, here is why Freedom isn’t free.

Typical supplement pricing is dependent on three factors: ingredients, quantity, and packaging. This list is largely in order of how much of an impact they have on price. Freedom’s price is mainly a result of the first one. I declined to pay $7-8/bottle for the packaging I wanted, and realistically if I had cheap ingredients, the cost per pill would be less.

Freedom is a combination nine different ingredients, which even without going into any more detail, would suggest it has to be more expensive than any single one of those ingredients.

In this case the combination isn’t actually what is driving up the price, I could have made Freedom cheaper. This spring I spent a lot of time talking with manufacturers, and received quotes that varied dramatically. Two in particular were almost eight times more than the others. Those two quotes were so far outside the other ones that I called those manufacturers and asked them why they were so much. Both of them had the same answer “we are quoting you the strongest potency, highest absorption rate ingredients.”

That floored me. I thought, generally speaking, cinnamon is cinnamon and pepper is pepper. The more I researched, the more I realized, the knock off version of ingredients is the easy way out. It is the route that all too many companies take in their quest to get a piece of the multi-billion dollar supplement market.

I founded Fully Human to be the better way of doing supplements. Fully Human isn’t going to beat Costco on price or quantity. It is the best brand you can buy. It will replace dozens of pills with two that give you the right amount at the right time, and deliver the right results.

That’s why after realizing the option was cheap ingredients or there really wasn’t a choice for me. If I was going to invent a new supplement formulation based on clinical research; I needed to use the ingredients that were as close to clinical quality as possible.

There are plenty of people who will keep telling me that Freedom is too expensive for them,and that is fine. I will not compromise quality to turn a profit. I will guarantee you that Freedom will be the best anti-inflammation supplement you have ever taken. If it doesn’t work – email me – I’ll refund you 200% of what you paid.

What do you have to lose?

The Little Things

Shipping Boxes. You never really think about them until you get a bad one. Then it is the only thing you can think of. For the past six months all I have been focused on is the development and manufacture of Freedom, and I never really thought about what happens when someone actually buys a bottle.

Ok that isn’t entirely true. I had nightmares that no one would buy it. And I had fantasies about it becoming the next fad for the likes of Tom Brady and Oprah. But the little thing about what I do with this super cool bottle of an invention I researched and labored on…what about that?

I mean I spent a lot of time working with graphic designers on the bottle. Figuring out the colors, shape, lid color, the metallic background. All these little things that normally I wouldn’t really pay attention to. All of that made me think I had everything figured out.

Turns out I didn’t.

I shipped the first bottles of Freedom yesterday night. In USPS Priority Envelopes. I thought it was a nice touch for me to pay extra to have the bottles shipped faster. But as I looked at the packaged bottles I realized…they looked shitty. Not like I had done a sloppy tape job, but like the way a present wrapped by a five year old looks.

Those of you who had enough faith to be the first to order are the ones who are getting the worst packaging. Yea, sorry about that. I really thought I had it together, but I had forgotten something I learned in during my time with special operations: The difference between good and great is measured in how well you do the basics. It isn’t about being amazing at one thing. It is doing the simple, little things well, over and over again.

I now have boxes perfectly sized for my bottles ordered and on their way. And I was thinking about getting rid of this pile of USPS Priority envelopes I brought home. But maybe I’ll keep them around, just to remind me that doing the little things well every time is what success is made of.

I’ll get back to work here, but while I’m busy re-learning life lessons, hopefully you remember to bring your full selves to life every day. If you are looking for a solution to your inflammation, check out Freedom, the first supplement to combine the eight most effective anti-inflammation compounds to give you a chance to fight inflammation naturally.

Freedom is here

It is finally here. Freedom was just delivered to our storage facility and we have begun the process of taking orders and smoothing out our fulfillment process.

It has been a long summer. And a longer journey to bring this first of it’s kind supplement to life. Being whole shouldn’t take dozens of pills. Not should you have to compromise your dreams because of inflammation and pain. And now we don’t have to make those trade-offs.

It isn’t particularly revolutionary, but it is amazing none the less. In just under six months we have gone from R&D, to formulation, to manufacturing and now we are beginning to ship to our early backers.

If you didn’t get a chance to order during our Indiegogo campaign, you can head over to the store to order some now.

Now that things are rolling again, I’ll be posting updates more often. But until next time, remember to bring your full self with you as you live life.

Its Time for Indian Takeout

If you are at all like me (which lets be honest you probably are because you are 1. reading | 2. a human | 3. breathing | 4. amazingly good looking | 5. really good at being awesome), then you enjoy Indian food. I know I know, I said I was going to be posting about ways to help fight inflammation, and I will – stick with me.

Turmeric

So back to Indian food – one of the key ingredients in about 93% of all Indian food (and American mustard) is Turmeric. It is a yellow spice that comes from the Curcuma longa, root (whatever that means), and has been used in Indian and Middle Eastern dishes at least as long as people have bothered to keep track. Turmeric has also been used as a herbal remedy for almost as long.

I like to imagine the first use of turmeric for medicine went something like this:

THE ‘OFficial’ first use of turmeric for medicine

Damnit Akshat!!! How many times have I told you that running through the garden ruins food! You know I have been working hard to make sure there is enough of the Curcuma for your sister’s wedding later this year, and now you went and sprained your ankle. Here – just chew on one of these roots for a while and get out of my way. Of course it will help – mother always knows best (well it will at least help me get you out of my garden)

The next day

Akshat – I thought you said your ankle was sprained – how are you able to walk so well? And how is there not more swelling? And where did the root go that I gave you to chew on – I need that for dinner tonight.

From there this mother took what ‘cured’ her son of swelling and began selling it in the market as a cure for stupid and or injured man children. And the age of humans using turmeric to fight inflammation began

But How Does It Work

So turmeric has an active ingredient curcumin (no not the spice cumin that you are using right now in your taco recipe – although similarly tasty), and this ingredient has both antioxidant and anti-inflammatory properties.

Clinical studies have found curcumin, when taken multiple times a day, in doses ranging from 400mg to 600mg per dose, offers protection against certain cancers, reduces the symptoms of osteoarthritis (there is limited research suggesting it also helps rheumatoid arthritis, but more is needed), fights the inflammation causing IBS (inflammatory bowl syndrome) and help stabilize blood sugar. There is also anecdotal evidence that curcumin protects neurons from the protein buildup which causes Alzheimer’s (research into this is ongoing in mice, but initial results are positive).

Great – but does it do more harm than good?

So the short answer is no – Turmeric is extremely safe for the majority of people. If you have a family (or personal) history of liver disease then you should probable avoid turmeric just to be safe though. Also, there is insufficient research into the safety of turmeric with pregnant women, so might as well err on the side of avoiding it so long as you are toting around that spare human.

I have been taking turmeric for about six years now, and have noticed a little heartburn if I take more than the recommended dose, but that could be a vestige of years of taking pain medications weakening my stomach lining.

Tomorrow I’ll talk about another awesome extract that I am a huge fan of — Green Tea — until then – you all stay classy, and don’t forget to bring your full selves to life.

Sources – no i didn’t just make all this up 🙂

American Cancer Society – cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/HerbsVitaminsandMinerals/turmeric

Consumerlab. consumerlab.com/tnp.asp?chunkiid=21874

Natural Health, Natural Medicine: The Complete Guide to Wellness and Self-Care for Optimum Health, by Andrew Weil.

Natural Database – naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=NONMP&s=ND&pt=100&id=662&fs=ND&searchid=37594816

If you are looking for a supplement that uses turmeric in the scientifically verified dose, with enough in a single bottle to let you take it at the clinical dose for a full month, check out my supplement Freedom over at Indiegogo.

Next time I’ll talk about green tea – or as I like to call it – the only good tea

Crowdfunding Round Is Live!

Fully Human is about bringing your full self to life, and doing that in a sustainable way. Our first ultra-premium supplement, Freedom, is about giving you just that. Freedom. It will be the first anti-inflammation nutritional supplement that delivers clinically researched, all natural compounds, to you – in the doses that research has shown will aid your body in reducing inflammation. Freedom is not a take-once-a-day supplement that will cure all your problems, because those products don’t exist. Research has shown that taking a supplement once a day isn’t the path to it fully working. We decided that our product needs to be take at the frequency that clinicians find to be most effective. In the case of Freedom, that is three times a day. As a vet I know that freedom takes work and commitment, but in the end freedom is always worth it.

I am launching Freedom on Indiegogo because:

    1. Indiegogo allows nutritional supplements to be funded.

    2. I don’t have the roughly $35,000 needed to research, manufacture and distribute Freedom.

    3. I am unwilling to be beholden to a venture capital or other more traditional lending service who may pressure me to compromise quality for profit. 

Check out the campaign: https://www.indiegogo.com/projects/fully-human-supplements/x/20552919#/

Or my video about Freedom:

 

Size May Not Matter – But Time Does

Wake Up.

Pour caffeine into my face.

Wait 20 minutes.

Begin day.

Does this sound like the start of your day? Cause it is basically how every day starts for me. When I was younger there were more steps in the beginning of my day, whether it was eating breakfast (now that doesn’t happen until about 4 hours after I wake up), working out (that is now every other day), or, taking my supplements (now I take my supplements at noon and about 5pm). I want to talk about why I started taking my supplements towards the middle and end of my day here.

Part of the reason I switched was because taking so many pills all at once on an empty stomach really upset me, and made it hard to focus for about an hour after taking them. But the more significant reason is that I learned the time of day matters when taking anything that your body digests, whether supplement, medication or really even food. Once you stop and think about it, which I never did, it makes a lot of sense. The body takes a few hours to process whatever you consume, and then that takes a further amount of time (varies by compound), to build up to its full effectiveness.

For instance, a Kansas State study found that acid reflux medicine nearly twice as many people saw a dramatic reduction in their symptoms when they took their daily medication around dinnertime. This is because acid tends to build up as you eat, and peak shortly before bed, so taking medicine in the morning has significantly less impact than taking it when acid is near its high point.

Freedom is an anti-inflammation supplement, and research has shown that individuals benefit most from anti-inflammation drugs and supplements when taken at specific times. Those times vary depending on the source of inflammation.

Individuals suffering from osteoarthritis (like me), or other forms of inflammation that are the result of ‘use’ (exercise/other activities) have their symptoms peak in the evening. A Texas Tech University study found that the optimum time for non-steroidal anti-inflammatory interventions (supplements, ibuprofen…etc) is between about noon and 4pm. This allows the compound time to digest and reach its highest blood levels around the time you would be experiencing peak inflammation.

Sufferers of rheumatoid arthritis, and other inflammation from autoimmune diseases see their worst inflammation in the morning, and according to the same Texas Tech study, benefit most from taking their anti-inflammation drugs/supplements as close to bedtime as practical, in order to prevent overnight inflammation growth.